ResearchVEGF
Genentech Biooncology

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VEGF and other common tumor markers in breast cancer

A variety of tumor markers are associated with breast cancer. These include estrogen receptors, the human epidermal receptor (HER-2/neu), and the breast cancer—1 gene (BRCA-1). Recent research has correlated several breast cancer tumor markers with vascular endothelial growth factor (VEGF) expression.

For more information on the relationship of VEGF and other tumor markers in breast cancer, click on the links in the table below.

Tumor MarkerFindingsStudies
Estrogen/estrogen receptor
  • VEGF expression may be regulated by estrogen
  • VEGF levels have been associated with response to antiestrogen therapy
  • VEGF has been correlated with ER-negative status
  • Buteau-Lozano et al, Cancer Res, 20027
  • Linderholm et al, J Clin Oncol, 20005
  • Fuckar et al, Int J Surg Pathol, 20068
HER-2
  • VEGF correlates with HER-2/neu positivity
  • Konecny et al, Clin Cancer Res, 20044
  • Fuckar et al, Int J Surg Pathol, 20068
BRCA-1
  • VEGF expression is controlled by an interaction of BRCA-1 and ER
  • Kawai et al, Oncogene, 200210

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Estrogen / ER

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