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The VEGF ligand and angiogenesis
Angiogenesis as a cancer hallmark
VEGF: The predominant mediator of angiogenesis
History of VEGF research
Summary
References
A specific approach to VEGF inhibition
Strategies for VEGF inhibition
Effects of direct VEGF inhibition
Versatility to address changing tumor biology
Summary
References
The need for continuous VEGF inhibition
Stability of VEGF
Continuousness of VEGF expression
What happens when VEGF inhibition is stopped?
Understanding tumor progression
Summary
References
The role of VEGF across tumor types
VEGF in breast cancer
Evidence of VEGF expression
VEGF and other tumor markers
VEGF beyond angiogenesis
Prevalence of VEGF-expressing tumors
VEGF and metastasis
VEGF and prognosis
VEGF as a predictive factor
Summary
References
VEGF in lung cancer
Evidence of VEGF expression
Prevalence of VEGF
VEGF and carcinogens
VEGF and prognosis
Summary
References
VEGF in colorectal cancer
Evidence of VEGF expression
VEGF and prognosis
VEGF as a predictive factor
Summary
References
VEGF in RCC
Biology of RCC
What is ubiquitination?
Unique role of VEGF in RCC pathogenesis
Evidence of VEGF expression in RCC
VEGF and prognosis in RCC
Summary
References
VEGF in glioblastoma
Glioblastomas, angiogenesis, and VEGF
Activation of the VEGF pathway in glioblastoma
Impact of VEGF on glioblastoma microvasculature
VEGF and tumorigenesis
VEGF as a prognostic factor
Summary
References
VEGF in prostate cancer
Evidence of VEGF expression in prostate cancer
The role of VEGF throughout the development of prostate cancer
VEGF as a prognostic indicator of disease progression
Summary
References
VEGF in ovarian cancer
VEGF-mediated angiogenesis in the functional reproductive cycle
VEGF expression in ovarian cancer
The multiple roles of VEGF throughout the development of ovarian cancer
VEGF as a prognostic factor in ovarian cancer
Summary
References
Slide decks and videos
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The role of VEGF across tumor types
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VEGF in RCC
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Full VEGF & angiogenesis sequence
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The role of VEGF in renal cell carcinoma (RCC)
VEGF in breast cancer
VEGF in lung cancer
VEGF in CRC
VEGF in GBM
VEGF in prostate cancer
VEGF in ovarian cancer
References for VEGF in renal cell carcinoma (RCC)
Bukowski R.
Kidney Cancer J
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Rini BI, Small EJ.
J Clin Oncol
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George DJ, Kaelin WG Jr.
N Engl J Med
. 2003;349:419-421.
Haase VH.
Kidney Int
. 2006;69:1302-1307.
American Cancer Society. What is kidney cancer? Available at:
http://www.cancer.org/docroot/CRI/content/CRI_2_2_1X_What_is_kidney
_cancer_22.asp?
Accessed October 24, 2006.
Iliopoulos O, Levy AP, Jiang C, Kaelin WG Jr, Goldberg MA.
Proc Natl Acad Sci USA
. 1996;93:10595-10599.
Huang LE, Gu J, Schau M, Bunn HF.
Proc Natl Acad Sci USA
. 1998;95:7987-7992.
Jacobsen J, Grankvist K, Rasmuson T, Bergh A, Landberg G, Ljungberg B.
BJU Int
. 2004;93:297-302.
Yildiz E, Gokce G, Kilicarslan H, Ayan S, Goze OF, Gultekin EY.
BJU Int
. 2004;93:1087-1093.
Tsuchiya N, Sato K, Akao T, et al.
Tohoku J Exp Med
. 2001;195:101-113.
Hemmerlein B, Kugler A, Ozisik R, Ringert RH, Radzun HJ, Thelen P.
Virchows Arch
. 2001;439:645-652.
Lee JS, Kim HS, Jung JJ, Park CS, Lee MC.
J Surg Oncol
. 2001;77:55-60.
Na X, Wu G, Ryan CK, Schoen SR, di'Santagnese PA, Messing EM.
J Urol
. 2003;170:588-592.
Nicol D, Hii SI, Walsh M, et al.
J Urol
. 1997;157:1482-1486.
Takahashi A, Sasaki H, Kim SJ, et al.
Cancer Res
. 1994;54:4233-4237.
Tomisawa M, Tokunaga T, Oshika Y, et al.
Eur J Cancer
. 1999;35:133-137.
Paradis V, Lagha NB, Zeimoura L, et al.
Virchows Arch
. 2000;436:351-356.
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