What is ubiquitination?
The role of ubiquitination in VHL function
Under normoxic conditions, HIF-1α is marked for degradation through a process known as ubiquitination. In ubiquitination, molecular tags, or ubiquitins, are added to HIF-1α, signaling that HIF-1α is to be destroyed through proteasome degradation. Dysregulation of the ubiquitination process causes HIF-1α to accumulate in the cell and induce expression of a number of gene products, including VEGF.3
George DJ, Kaelin WG Jr. N Engl J Med. 2003;349:419-421. Copyright © 2003 Massachusetts Medical Society.
Ubiquitination is a cellular regulatory process in which proteins called ubiquitins are added to another, larger protein—the target protein. This process acts as a signal for the target protein to undergo degradation. Under normoxic conditions and with normal von Hippel-Lindau gene (VHL) function, the VHL protein (pVHL) plays a role in the ubiquitination and subsequent degradation of hypoxia-inducible factor-1α (HIF-1α).3,4,7
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