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• VEGF and disease progression

VEGF levels increase as disease progresses

Serum VEGF levels increase over the course of disease

In a 2006 study, Eriksson et al showed a statistically significant increase in serum VEGF levels from the time of diagnosis until the time of death in patients with NSCLC. This image shows serum VEGF and basic fibroblast growth factor (bFGF) levels for one study patient during treatment and until time of death.⁴

Reprinted with permission from Neoplasma. 2006;53:285-290.

One measure of the importance of vascular endothelial growth factor (VEGF) throughout the natural history of lung cancer is its presence at various stages of disease. In a recent study of 45 patients with stage III non-small cell lung cancer (NSCLC), Eriksson and colleagues showed that there was a statistically significant (P=0.0004) increase in serum VEGF levels from the time of pathological diagnosis until the time of death. The clinical significance of this finding is not yet known.⁴

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