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History of VEGF research
The VEGF ligand and angiogenesis
Angiogenesis as a cancer hallmark
VEGF: The predominant mediator of angiogenesis
History of VEGF research
Summary
References
A specific approach to VEGF inhibition
Strategies for VEGF inhibition
Effects of direct VEGF inhibition
Versatility to address changing tumor biology
Summary
References
The need for continuous VEGF inhibition
Stability of VEGF
Continuousness of VEGF expression
What happens when VEGF inhibition is stopped?
Understanding tumor progression
Summary
References
The role of VEGF across tumor types
VEGF in breast cancer
Evidence of VEGF expression
VEGF and other tumor markers
VEGF beyond angiogenesis
Prevalence of VEGF-expressing tumors
VEGF and metastasis
VEGF and prognosis
VEGF as a predictive factor
Summary
References
VEGF in lung cancer
Evidence of VEGF expression
Prevalence of VEGF
VEGF and carcinogens
VEGF and prognosis
Summary
References
VEGF in colorectal cancer
Evidence of VEGF expression
Angiogenic switch activation
VEGF expression by stage
Angiogenesis and apoptosis
VEGF and prognosis
Survival
Increased risk of relapse
Metastasis
Tumor involvement / lymph node involvement
VEGF as a predictive factor
Adjuvant fluoropyrimidines
Preoperative radiotherapy
Summary
References
VEGF in RCC
Biology of RCC
Unique role of VEGF in RCC pathogenesis
Evidence of VEGF expression in RCC
VEGF and prognosis in RCC
Summary
References
VEGF in glioblastoma
Glioblastomas, angiogenesis, and VEGF
Activation of the VEGF pathway in glioblastoma
Impact of VEGF on glioblastoma microvasculature
VEGF and tumorigenesis
VEGF as a prognostic factor
Summary
References
Slide decks and videos
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The role of VEGF across tumor types
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VEGF in colorectal cancer
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Full VEGF & angiogenesis sequence
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The role of VEGF in colorectal cancer (CRC)
VEGF in breast cancer
VEGF in lung cancer
VEGF in RCC
VEGF in GBM
References for VEGF in colorectal cancer
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Oncol Rep
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Cell
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Kuramochi H, Hayashi K, Uchida K, et al.
Clin Cancer Res
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Ottaiano A, Franco R, Talamanca AA, et al.
Clin Cancer Res
. 2006;12:2795-2803.
Saad RS, Kordunsky L, Liu YL, Denning KL, Kandil HA, Silverman JF.
Mod Pathol
. 2006;19:1317-1323.
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