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Evidence from numerous studies and analyses points to vascular endothelial growth factor (VEGF) and angiogenesis as prognostic factors in colorectal cancer. For information on a particular outcome that has been correlated with VEGF expression, click on the links in the table below.
| Outcome | Study Type and Size | Source |
| Poor survival | Clinical study (N=60) Meta-analysis of 27 studies | Ishigami et al, Br J Cancer, 19985
Des Guetz et al, Br J Cancer, 20064 |
| Increased risk of relapse | Meta-analysis of 27 studies | Des Guetz et al, Br J Cancer, 20064 |
| Metastasis | Clinical study (N=133) Clinical study (N=60) Clinical study (N=31) | Tanigawa et al, Cancer Res, 199713
Ishigami et al, Br J Cancer, 19985 Kuramochi et al, Clin Cancer Res, 200614 |
| Tumor invasion and lymph node involvement | Clinical study (N=72) Clinical study (N=90) | Ottaiano et al, Clin Cancer Res, 200615
Saad et al, Mod Pathol, 200616 |
