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VEGF and angionesis in breast cancer

"Angiogenesis, the process of new blood vessel formation, plays a central role in both local tumor growth and distant metastasis in breast cancer."— Schneider et al, J Clin Oncol, 2005.¹

Breast cancer is one of the tumor types in which vascular endothelial growth factor (VEGF) has been implicated as a key mediator of angiogenesis. It has been shown that

• VEGF is expressed in a variety of breast cancer types^2-5
• VEGF is involved throughout the breast tumor life cycle⁶
• VEGF expression is related to other breast cancer tumor markers^7-10
• VEGF expression correlates with poor prognosis in breast cancer^3,4,11

Although scientists and clinicians have learned much about the role of VEGF and angiogenesis in breast cancer, many questions remain unanswered and research on this exciting topic remains robust.

For more information on VEGF and angiogenesis in breast cancer, click on the links below.

In This Section

• What is the evidence of VEGF expression in breast cancer?
• Is there a relationship between VEGF and other breast cancer markers?
• Does VEGF have nonangiogenic effects in breast cancer?
• What is the prevalence of VEGF-expressing tumors?
• What is the relationship between VEGF and metastasis?
• What are the prognostic implications of VEGF?
• Is VEGF a predictive factor in breast cancer?
• Summary of VEGF in breast cancer
• References for VEGF in breast cancer

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