• Home
• |
• Site Map

Site map

• The VEGF ligand and angiogenesis
  • Angiogenesis as a cancer hallmark
    • The angiogenic process
    • Angiogenesis in tumor growth
  • VEGF: The predominant mediator of angiogenesis
    • Detailed look at the VEGF pathway
      • Triggers of VEGF production
      • VEGF expression / angiogenic switch
      • VEGF receptors
      • Post-receptor signaling
    • VEGF in tumor growth
      • Growth and survival of tumor blood vessels
      • Formation of abnormal vasculature
      • Increase in interstitial pressure
      • Immune response and other effects
  • History of VEGF research
    • Landmark papers
    • Role of Genentech BioOncology
  • Summary
  • References
• A specific approach to VEGF inhibition
  • Strategies for VEGF inhibition
  • Effects of direct VEGF inhibition
  • Summary
  • References
• The need for continuous VEGF inhibition
  • Stability of VEGF
  • Continuousness of VEGF expression
  • What happens when VEGF inhibition is stopped?
  • Understanding tumor progression
  • Summary
  • References
• The role of VEGF across tumor types
  • VEGF in breast cancer
    • Evidence of VEGF expression
      • VEGF: A critical factor
      • VEGF expressed throughout the tumor life cycle
      • VEGF and MVD
      • Pattern of angiogenesis
    • VEGF and other tumor markers
      • Estrogen / ER
      • HER2
      • BRCA-1
    • VEGF beyond angiogenesis
    • Prevalence of VEGF-expressing tumors
    • VEGF and metastasis
    • VEGF and prognosis
    • VEGF as a predictive factor
    • Summary
    • References
  • VEGF in lung cancer
    • Evidence of VEGF expression
      • VEGF and disease progression
      • VEGF and vasculature location
    • Prevalence of VEGF
    • VEGF and carcinogens
    • VEGF and prognosis
      • Survival
      • Malignant pleural effusion
    • Summary
    • References
  • VEGF in colorectal cancer
    • Evidence of VEGF expression
      • Angiogenic switch activation
      • VEGF expression by stage
      • Angiogenesis and apoptosis
    • VEGF and prognosis
      • Survival
      • Increased risk of relapse
      • Metastasis
      • Tumor involvement / lymph node involvement
    • VEGF as a predictive factor
      • Adjuvant fluoropyrimidines
      • Preoperative radiotherapy
    • Summary
    • References
  • VEGF in RCC
    • Biology of RCC
      • What is ubiquitination?
    • Unique role of VEGF in RCC pathogenesis
    • Evidence of VEGF expression in RCC
    • VEGF and prognosis in RCC
    • Summary
    • References
  • VEGF in GBM
    • Glioblastomas, angiogenesis and VEGF
    • Activation of the VEGF pathway in GBM
    • Impact of VEGF on GBM microvasculature
    • VEGF and tumorigenesis
    • VEGF as a prognostic factor
    • Summary
    • References
• Slide decks and videos
• E-mail updates