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5 Critical questions in the science of VEGF and angiogenesis

  1. Question 1 preview icon - “Why is the VEGF ligand essential throughout tumor development?”Why is the VEGF ligand essential throughout tumor development?Arrow pointing downward from the thumbnail preview to the featured question detail below
  2. Question 2 preview icon - “What are the strategies for inhibiting the VEGF pathway?”What are the strategies for inhibiting the VEGF pathway?Arrow pointing downward from the thumbnail preview to the featured question detail below
  3. Question 3 preview icon - “What are the effects of direct VEGF ligand inhibition?”What are the effects of direct VEGF ligand inhibition?Arrow pointing downward from the thumbnail preview to the featured question detail below
  4. Question 4 preview icon - “Why is continued VEGF inhibition important?”Why is continued VEGF inhibition important?Arrow pointing downward from the thumbnail preview to the featured question detail below
  5. Question 5 preview icon - “Why do tumors progress?”Why do tumors progress?Arrow pointing downward from the thumbnail preview to the featured question detail below
Why is the VEGF ligand essential throughout tumor development?
The VEGF ligand may play an essential role throughout tumor development by helping tumor vessels establish, grow, and survive1
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What are the strategies for inhibiting the VEGF pathway?
The 2 primary strategies for VEGF pathway inhibition include targeting either the VEGF ligand or the VEGF receptor2
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What are the effects of direct VEGF ligand inhibition?
Direct VEGF ligand inhibition may result in regression of existing tumor vasculature and inhibition of new and recurrent tumor vessel growth3-7
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Why is continued VEGF inhibition important?
Regrowth of tumor vasculature—at a rate consistent with normal tumor development—may occur when VEGF inhibition is stopped8,9
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Why do tumors progress?
Tumor progression may occur through acquired resistance (with agents that target the tumor directly) or through the activation of secondary pathways (with agents that target VEGF directly)10-12
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  1. Why is the VEGF ligand essential throughout tumor development?

  2. What are the strategies for inhibiting the VEGF pathway?

  3. What are the effects of direct VEGF ligand inhibition?

  4. Why is continued VEGF inhibition important?

  5. Why do tumors progress?

VEGF across tumor types

Learn about the role VEGF plays across tumor types.